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  • Title: Immunohistological analysis of Rosai-Dorfman histiocytosis. A disease of S-100 + CD1-histiocytes.
    Author: Bonetti F, Chilosi M, Menestrina F, Scarpa A, Pelicci PG, Amorosi E, Fiore-Donati L, Knowles DM.
    Journal: Virchows Arch A Pathol Anat Histopathol; 1987; 411(2):129-35. PubMed ID: 3111077.
    Abstract:
    Five cases of Rosai-Dorfman histiocytosis (RDH) (also called Sinus Histiocytosis with Massive Lymphoadenopathy; SHML) have been studied by immunohistochemical methods with heteroantisera and monoclonal antibodies. One case was also studied by Southern blot hybridization analysis with DNA probes specific for T cell receptor beta chain and immunoglobulin heavy chain. Immunophenotyping of large histiocytes, characteristic of RDH, evidenced the presence of S-100 protein and the absence of CD1 and other markers usually found in histiocytes and macrophages. DNA hybridization study showed the absence of clonal T or B lymphoid populations.
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