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  • Title: Induction of hepatic cytochrome P-450c-dependent monooxygenase activities by dantrolene in rat.
    Author: Jayyosi Z, Totis M, Souhaili H, Goulon-Ginet C, Livertoux MH, Batt AM, Siest G.
    Journal: Biochem Pharmacol; 1987 Aug 01; 36(15):2481-7. PubMed ID: 3111484.
    Abstract:
    The effect of dantrolene sodium, a skeletal muscle relaxant, on drug metabolizing enzymes has been investigated after treatment of rats with a dose of 200 mg/kg for five days. We observed an induction of cytochrome P-450c and epoxide hydrolase in immunoassays and activities. An enhancement of the UDP-glucuronosyltransferase (GT1) activity was observed. We also reported a decrease of both liver cytochrome P-450 content and microsomal cytochrome P-450b dependent N-demethylation activities. On the other hand, the binding of dantrolene on microsomal cytochrome P-450 produced a type I difference spectrum, these data were obtained with liver microsomal cytochrome P-450c induced by 3-methylcholanthrene.
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