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  • Title: Effects of alfentanil on the pressor and catecholamine responses to tracheal intubation.
    Author: Crawford DC, Fell D, Achola KJ, Smith G.
    Journal: Br J Anaesth; 1987 Jun; 59(6):707-12. PubMed ID: 3111508.
    Abstract:
    The effects of alfentanil (given during induction of anaesthesia) on the haemodynamic and catecholamine responses to tracheal intubation were studied in 44 adult patients who received alfentanil 10 micrograms kg-1 or 40 micrograms kg-1, or saline placebo. Alfentanil 10 micrograms kg-1 and 40 micrograms kg-1 prevented any increase in heart rate and arterial pressure after tracheal intubation. Alfentanil 40 micrograms kg-1 produced profound hypotension and bradycardia. The use of alfentanil in both doses was associated with a decrease in plasma adrenaline concentrations after tracheal intubation.
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