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  • Title: Excito-repellent activity of β-caryophyllene oxide against Aedes aegypti and Anopheles minimus.
    Author: Nararak J, Sathantriphop S, Kongmee M, Mahiou-Leddet V, Ollivier E, Manguin S, Chareonviriyaphap T.
    Journal: Acta Trop; 2019 Sep; 197():105030. PubMed ID: 31121148.
    Abstract:
    Contact irritant and non-contact repellent activities of β-caryophyllene oxide were evaluated against laboratory strains of female Aedes aegypti (USDA strain), a major arbovirus vector and Anopheles minimus (KU strain), a major malaria parasite vector, compared with the synthetic repellent DEET, using an excito-repellency test system. β-caryophyllene oxide and DEET were tested at concentrations of 0.1, 0.25, 0.5 and 1.0% (v/v). Anopheles minimus was found to be more sensitive to β-caryophyllene oxide than that of Ae. aegypti and exhibited high avoidance response rates (86-96% escape) at 0.5% and 1.0% concentrations in contact and non-contact trials compared with Ae. aegypti (22-59% escape). However, at the same concentrations, DEET displayed lower irritancy and repellency capacities against these two mosquito species (range 0-54% escape) compared to β-caryophyllene oxide. The analysis of escape responses showed significant differences between mosquito species at all concentrations (P < 0.05) except for 0.1%. For both species, there were significant differences in irritant and repellent responses between β-caryophyllene oxide and DEET at higher concentrations (0.5 and 1.0%).
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