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  • Title: Surface marker studies on activated peripheral blood lymphocytes in idiopathic dilated cardiomyopathy.
    Author: Takamoto T, Hori Y, Takenaga M, Matsuo Y, Yokoyama MM, Koga Y, Toshima H.
    Journal: J Clin Lab Immunol; 1987 Apr; 22(4):157-61. PubMed ID: 3112402.
    Abstract:
    Expression of interleukin 2 (IL-2) receptor on peripheral blood lymphocytes after stimulation with concanavalin A (Con A) or anti-T3 monoclonal antibody was analyzed in patients with dilated cardiomyopathy (DCM) in order to clarify the abnormalities of lymphocyte activation mechanism in DCM. The expression of IL-2 receptor after the stimulation with either Con A or anti-T3 monoclonal antibody was found to be reduced in the patients with DCM when the results were compared with those of controls. A significant correlation was noticed between the expression of IL-2 receptor after Con A stimulation and T4+/T8+ cell ratio, and between the expression of IL-2 receptor after anti-T3 monoclonal antibody stimulation and the left ventricular end-diastolic pressure (LVEDP). The results suggest that there are abnormalities of lymphocyte activation in DCM and that the alteration may be associated with the cause or clinical conditions of DCM.
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