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  • Title: Autophagy induced by avian reovirus enhances viral replication in chickens at the early stage of infection.
    Author: Niu X, Zhang C, Wang Y, Guo M, Ruan B, Wang X, Wu T, Zhang X, Wu Y.
    Journal: BMC Vet Res; 2019 May 24; 15(1):173. PubMed ID: 31126305.
    Abstract:
    BACKGROUND: Avian reovirus (ARV) is an important pathogen that can cause serious disease in poultry. Though several in vitro studies revealed some molecular mechanisms that are responsible for ARV-induced autophagy, it is still largely unknown how ARV manipulates autophagy to promote its own propagation. RESULTS: In this study, we demonstrated that ARV infection triggered autophagy in chicken tissues, evident from the enhancement of LC3-I/-II conversion and the appearance of abundant autophagosomes. Moreover, viral replication and the expression of IL-1β were coupled with the process of ARV-induced autophagy in the early stage of infection. Furthermore, regulation of autophagy affected the accumulation of LC3-II, the production of ARV and the expression of IL-1β. CONCLUSIONS: Altogether, our data suggest that ARV induces autophagy, which benefits its replication and dissemination in chicken tissues at the early infection stage.
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