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  • Title: Induction of the placental form of glutathione S-transferase by lead nitrate administration in rat liver.
    Author: Roomi MW, Columbano A, Ledda-Columbano GM, Sarma DS.
    Journal: Toxicol Pathol; 1987; 15(2):202-5. PubMed ID: 3112922.
    Abstract:
    The administration of a single dose of lead nitrate to male Wistar rats caused an increase of a polypeptide in the liver cytosol that cross reacted with the anti-rat antibody of the placental form of glutathione S-transferase (GST-P). GST-P appeared when doses of lead that induced liver cell proliferation were given (5 and 10 micromoles/100 g of body weight). Recently, it has been shown that rat hepatic nodules also exhibited an increased content of the placental form of GST-P. The induction of GST-P by lead together with other biochemical effects exerted in the liver by this metal, suggests that some chemicals may induce in rat liver a biochemical pattern similar, in some aspects, to that exhibited by carcinogen-induced hepatocyte nodules.
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