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  • Title: Tissue-type plasminogen activator and streptokinase induce platelet hyperaggregability in the rabbit.
    Author: Ohlstein EH, Storer B, Fujita T, Shebuski RJ.
    Journal: Thromb Res; 1987 May 15; 46(4):575-85. PubMed ID: 3112993.
    Abstract:
    The ex vivo aggregability of rabbit platelets was assessed after rabbits were treated in vivo with thrombolytic doses of tissue plasminogen activator (t-PA) or streptokinase (SK). t-PA was evaluated at 2 doses; an effective thrombolytic dose of 10 micrograms/kg/min, i.v. and a higher dose of 30 micrograms/kg/min, i.v.. At both concentrations, ex vivo platelet hyperaggregability was observed when collagen, arachidonic acid or ADP were employed as the aggregating agonists. Significant falls in circulating platelet counts were observed after t-PA infusion. Infusion of SK also resulted in ex vivo platelet hyperaggregation. These data reveal that thrombolytic therapy may result in hyperaggregable platelets which may play a role in reocclusion of successfully recanalized blood vessels.
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