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  • Title: II. Mechanism of increased colony formation of CFU-S and CFU-C after in vivo PHA administration in mice.
    Author: Louwagie AC.
    Journal: Haematologia (Budap); 1977; 11(3-4):321-30. PubMed ID: 311310.
    Abstract:
    In vivo administration of 3 mg PHA-M results in an increase in spleen colonies due to an augmented seeding of CFU-S into the spleen. An increase in the number of CFU-S in the developing nine-day spleen colonies also occurred together with a slight increase in the number of CFU-S in DNA-S phase 24 hours after PHA-M administration. The increased colony formation was due to an increased number of CFU-C from the early culture period onwards but could not be explained by an increase in the number of CFU-C in DNA/S phase. The release of colony-stimulating substances was proved but this only partially accounted for the observed rise in bone marrow CFU-C.
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