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  • Title: Biocontrol effect of Kluyveromyces lactis on aflatoxin expression and production in Aspergillus parasiticus.
    Author: Ghanbari R, Rezaie S, Noorbakhsh F, Khaniki GJ, Soleimani M, Aghaee EM.
    Journal: FEMS Microbiol Lett; 2019 May 01; 366(10):. PubMed ID: 31132114.
    Abstract:
    Aspergillus parasiticus is one of the most common fungi able to produce aflatoxins, which are naturally occurring carcinogenic substances. This study evaluated the effects of the safe yeast, Kluyveromyces lactis, on fungal growth, aflatoxin production and expression of aflR gene in A. parasiticus. Antifungal susceptibility was evaluated by exposing A. parasiticus to different amounts of K. lactis, and aflatoxin production was measured using high-performance liquid chromatography. Expression of the aflR gene was determined by measuring the cognate aflR mRNA level by quantitative real-time reverse-transcription polymerase chain reaction assay. The growth of A. parasiticus was inhibited by 7 days of incubation at 30°C with a minimum population of 1.5 × 105 CFU/ml of K. lactis, which also suppressed expression of the A. parasiticus aflR gene, reducing the total production of aflatoxins by 97.9% and aflatoxins B1, B2, G1 and G2 by 97.8, 98.6, 98 and 94%, respectively. Accordingly, K. lactis could be considered as a potential biocontrol agent against toxigenic molds in food and animal feed.
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