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  • Title: Conversion of linoleic acid and arachidonic acid by skin epidermal lipoxygenases.
    Author: Nugteren DH, Kivits GA.
    Journal: Biochim Biophys Acta; 1987 Sep 04; 921(1):135-41. PubMed ID: 3113487.
    Abstract:
    Two different lipoxygenases have been identified in human and rat epidermis. One lipoxygenase has a (n-9)-specificity, converts arachidonic acid into 12-hydroxyeicosatetraenoic acid (12-HETE), and has been described by several investigators. Linoleic acid is not a substrate for this enzyme. The other lipoxygenase, with (n-6)-specificity, converts arachidonic acid into 15-HETE and linoleic acid into 13-hydroxyoctadecadienoic acid (13-HOD). Especially the latter lipoxygenase is thought to be involved in the regulation of the differentiation of the skin cells into a proper water-barrier layer. Linoleate is supposed to be the physiological substrate; this fatty acid is especially present in characteristic sphingolipids with unique structures.
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