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  • Title: Heterogeneity of hepatic microsomal UDP-glucuronosyltransferases activities: use and comparison of differential inductions in some mammalian species.
    Author: Boutin JA, Antoine B, Fournel S, Siest G.
    Journal: Comp Biochem Physiol B; 1987; 87(3):513-22. PubMed ID: 3113821.
    Abstract:
    1. The co-injection in rats of the inducers 3-methylcholanthrene or phenobarbital and of a protein synthesis inhibitor (cycloheximide) shows that two clusters of hepatic UDP-Glucuronosyltransferases (GT1 and GT2) are under separate genomic expression and differentially regulated. 2. The administration of cycloheximide alone even suggests a distinct turn-over for these two groups of isoenzymes. 3. Indirect evidence for a UDPGT isoform specialized for some structurally-related exogenous substrates, the monoterpenoid alcohols, is brought. Their conjugation exhibits a small deficiency and a marked response to phenobarbital treatment in the Gunn rat and an exclusive inducibility by phenobarbital in the guinea-pig.
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