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Title: Downregulation of LINC00515 in high-grade serous ovarian cancer and its relationship with platinum resistance. Author: Ni MW, Zhou J, Zhang YL, Zhou GM, Zhang SJ, Feng JG, Xu Q, Zhou Y, Mou HZ, Zheng ZG. Journal: Biomark Med; 2019 May; 13(7):535-543. PubMed ID: 31140829. Abstract: Aim: To investigate the expression of long intergenic noncoding RNA 00515 (LINC00515) in high-grade serous ovarian cancer (HGSOC) and its potential correlation with platinum resistance. Patients & methods: Expression of LINC00515 in HGSOC (n = 115) and normal (n = 19) tissues was detected via quantitative real-time PCR (qRT-PCR). We further explored the statistical significance of the relationship between LINC00515 expression and platinum resistance in HGSOC. Results: LINC00515 was gradually downregulated in the order of normal > platinum-sensitive > platinum-resistant tissue (p < 0.05). Results demonstrated that LINC00515 downregulation was correlated with platinum resistance and relapse-free survival (RFS) of HGSOC (p < 0.05). Conclusion: LINC00515 downregulation is correlated with HGSOC development, platinum resistance and RFS, supporting its utility as a potential biomarker to predict platinum resistance and prognosis of RFS.[Abstract] [Full Text] [Related] [New Search]