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  • Title: A naphthalimide-aminal-based pH-sensitive fluorescent donor for lysosome-targeted formaldehyde release and fluorescence turn-on readout.
    Author: Xu H, Ma S, Liu Q, Huang L, Wu P, Liu X, Huang Y, Wang X, Xu H, Lou K, Wang W.
    Journal: Chem Commun (Camb); 2019 Jun 21; 55(49):7053-7056. PubMed ID: 31143885.
    Abstract:
    A naphthalimide-aminal-based fluorescent donor (NAP-FAD-1) is a pH-sensitive smart donor, which features accelerated FA release at pH 5.0 compared to that at pH 7.4 and fluorescence turn-on readout for facile tracking and quantification of FA release. Confocal imaging studies of HeLa cells co-incubated with Lyso-Tracker Red suggested that its FA release is lysosome-targeted.
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