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  • Title: Intraspecific cross-protection in mice immunized with irradiated Schistosoma mansoni cercariae.
    Author: Lewis FA, Winestock J, Dingaan B, Richards C, Dean DA.
    Journal: J Parasitol; 1987 Aug; 73(4):787-91. PubMed ID: 3114466.
    Abstract:
    Several laboratory-maintained strains of Schistosoma mansoni were tested for their relative immunogenicity or susceptibility to anti-schistosome immunity in irradiated cercaria-immunized mice. A total of 11 strains and substrains were used; 7 were of Puerto Rican origin, 3 from Brazil, and 1 from Egypt. Mice were immunized by percutaneous exposure to 50-krad-irradiated cercariae. Immunity was assessed following challenge with cercariae of the homologous or a heterologous strain. The results showed that the choice of either the challenge or immunizing strains was not critical in the development of significant levels of protection. Extensive degrees of cross-protection developed in all intrastrain combinations tested.
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