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  • Title: Tamarin model of pneumococcal bacteremia.
    Author: Chudwin DS, Artrip SG, Ogden JD, Schiffman G.
    Journal: J Med Primatol; 1987; 16(4):249-60. PubMed ID: 3114496.
    Abstract:
    Tamarins (Saguinus labiatus) were utilized to study host defenses against pneumococcal bacteremia. Tamarins had a poor antibody response to immunization with varying doses of pneumococcal capsular polysaccharide (PCP) vaccine (2 of 15 positive) or to infection with serotype 7F Streptococcus pneumoniae (2 of 14 positive). Tamarins were protected against challenge with a lethal dose of serotype 7F S. pneumoniae if the bacteria were preopsonized with human immune globulin intravenous or if the tamarins were injected with the immune globulin 30 min before challenge. There was minimal protection utilizing a mouse monoclonal anti-type 7F PCP antibody.
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