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  • Title: Functional characterisation of interleukin 34 in grass carp Ctenopharyngodon idella.
    Author: Xue Y, Jiang X, Gao J, Li X, Xu J, Wang J, Gao Q, Zou J.
    Journal: Fish Shellfish Immunol; 2019 Sep; 92():91-100. PubMed ID: 31146007.
    Abstract:
    Interleukin (IL) 34 plays an important role in regulating macrophage functions and inflammation process. IL-34 homologues have recently been discovered in fish but the functions have not been studied. In this study, an IL-34 homologue was identified in grass carp Ctenopharyngodon idella and its bioactivities were investigated. The grass carp IL-34 was constitutively expressed in tissues, with the highest expression detected in spleen. It could be up-regulated in spleen after infection with F. cloumnare and grass carp reovirus II, and in primary head kidney leucocytes by recombinant IL-4/13B. The recombinant IL-34 produced in bacteria and HEK293T cells showed stimulatory effect on the expression of IL-1β, IL-6 and IL-8 but inhibited expression of IL-10 and TGF-β1 in primary head kidney macrophages. The results demonstrate that IL-34 is a proinflammatory cytokine in grass carp.
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