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  • Title: The role of genes LAC1 and LAC2 in the biosynthesis of lactose metabolism enzymes by Kluyveromyces lactis.
    Author: Boze H, Nicol D, Moulin G, Galzy P.
    Journal: Acta Microbiol Hung; 1987; 34(1):73-83. PubMed ID: 3115053.
    Abstract:
    By crossing different Kluyveromyces lactis strains, the role of genes LAC1, LAC2 and of gene C were analyzed. These genes are involved in the biosynthesis of enzymes for the metabolism of lactose and galactose. They control the biosynthesis of the lactose and galactose transport, of beta-galactosidase and of the three enzymes of the Leloir pathway. The presence of at least one of the LAC gene is required for the biosynthesis to occur. The gene C seems to code for a negative factor which blocks the expression of the LAC1 and LAC2 genes in the absence of an inducer.
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