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  • Title: Effects of calcium and A23187 on deformability and volume of human red blood cells.
    Author: Dodson RA, Hinds TR, Vincenzi FF.
    Journal: Blood Cells; 1987; 12(3):555-64. PubMed ID: 3115342.
    Abstract:
    Human red blood cells treated in vitro with Ca2+ plus A23187 in low K+ medium exhibited significantly decreased cell volume and deformability, the latter determined by ektacytometry. These effects of Ca2+ plus A23187 were prevented in the presence of high K+ medium. Increased K+ permeability mediated by increased intracellular Ca2+ (Gardos effect) was apparently responsible for decreased cell volume and deformability in low K+ medium. Although it is commonly accepted that Ca2+ accumulation and/or ATP depletion per se cause decreased red blood cell deformability, the present results demonstrate that acutely induced changes in red blood cell volume as promoted by Ca2+ are a more important determinant of red blood cell deformability.
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