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  • Title: Evidence for gonadal desensitization after pulsatile therapy in women with amenorrhoea?
    Author: Glasier A, Baird DT, McNeilly AS.
    Journal: Clin Endocrinol (Oxf); 1987 Apr; 26(4):441-51. PubMed ID: 3115631.
    Abstract:
    Sixteen women with primary and secondary amenorrhoea were treated with pulsatile GnRH administered subcutaneously. Ovulation was successfully induced in 6/8 women with hypogonadotrophic hypogonadism; and in 2/2 women with idiopathic hyperprolactinaemia; but in only 3/6 women with amenorrhoea associated with an elevated LH:FSH ratio. Using serial blood sampling, we were unable to demonstrate the establishment of a physiological pattern of gonadotrophin secretion in the presence of an apparently normal menstrual cycle. Nor did we observe a consistent relationship between injection of GnRH and the resultant gonadotrophin response. A reduction or total cessation of both pituitary and gonadal sensitivity to GnRH was observed in four women. Possible reasons for these findings are discussed.
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