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  • Title: Determination of valproic acid and its metabolites by gas chromatography-mass spectrometry with selected ion monitoring.
    Author: Tatsuhara T, Muro H, Matsuda Y, Imai Y.
    Journal: J Chromatogr; 1987 Jul 24; 399():183-95. PubMed ID: 3116023.
    Abstract:
    A modified method for the determination of valproic acid, its eleven metabolites and their conjugates in small samples of serum and urine by gas chromatography-mass spectrometry with selected-ion monitoring was developed. Valproic acid and its eleven metabolites were determined in serum and urine of epileptic patients treated with valproic acid. 2-Hydroxy-2-propylpentanoic acid was identified as a new metabolite of valproic acid in the urine of 11 of the 12 patients. The unsaturated metabolites, such as (Z)- and (E)-2-propyl-2-pentenoic acid, were found to be predominantly excreted as glucuronides. 3-Hydroxy-2-propylpentanoic acid and 2-propylglutaric acid were also excreted as glucuronides.
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