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  • Title: [Contamination of wheat flour with the toxigenic strain of Penicillium islandicum Sopp and the embryotoxic effect of its secondary metabolites in the chick embryo].
    Author: Veselý D, Veselá D, Tichá J.
    Journal: Vet Med (Praha); 1987 Jul; 32(7):435-9. PubMed ID: 3116746.
    Abstract:
    Material milled and sampled in 1986 in one Prague flour mill included two flour batches contaminated with a toxicogenic strain of Penicillium islandicum Sopp. P. islandicum, cultivated under experimental conditions, yielded the total of eight grams of chloroform extract containing three grams of luteoskyrin from a kilogram of wheat. The effective dose of chloroform extract was 0.8 microgram (0.5-1.8) for a two-day old chicken embryo, 2.0 microgram (1.7-2.6) for a three-day old embryo and 2.8 micrograms (1.7-4.7) for a four-day old embryo. On all days of administration the chloroform extract had a strong teratogenous action. The most frequent malformations included microophthalmia and anophthalmia, cerebral hernia, bilaterally cleft beak, and reduction deformities of the extremities.
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