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  • Title: Chloroquine resistance of Plasmodium berghei: biochemical basis and countermeasures.
    Author: Salganik RI, Pankova TG, Chekhonadskikh TV, Igonina TM.
    Journal: Bull World Health Organ; 1987; 65(3):381-6. PubMed ID: 3117393.
    Abstract:
    Microsomal monooxygenases, enzymes that metabolize xenobiotics, may be responsible for the chloroquine resistance of malarial parasites. Plasmodium cells contain cytochrome P-450 and exhibit aryl hydrocarbon hydroxylase and aminopyrine N-dimethylase activity, two monooxygenases that inactivate chloroquine. The activities of these monooxygenases are considerably higher in chloroquine-resistant strains of Plasmodium berghei than in the chloroquine-sensitive strain of the parasite. Inhibitors of microsomal monooxygenases have the potential to overcome the chloroquine resistance of Plasmodium spp., and, of those inhibitors tested, the copper-lysine complex, copper(lysine)(2), was the most effective.
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