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  • Title: Suppression of the chloroquine resistance of Plasmodium berghei by treatment of infected mice with a microsomal monooxygenase inhibitor.
    Author: Rabinovich SA, Kulikovskaya IM, Maksakovskaya EV, Chekhonadskikh TV, Pankova TG, Salganik RI.
    Journal: Bull World Health Organ; 1987; 65(3):387-9. PubMed ID: 3117394.
    Abstract:
    Administration of a combination of chloroquine and the copper-lysine complex, copper(lysine)(2), an inhibitor of microsomal monooxygenases, considerably decreased the parasitaemia level of mice infected with a chloroquine-resistant strain of Plasmodium berghei. When given separately, chloroquine and the complex had no antimalarial effect. Use of a combination of monooxygenase inhibitors and chloroquine therefore appears to be a promising addendum to the chemotherapy of malaria caused by chloroquine-resistant parasites.
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