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  • Title: Differences in the association between glycemia and uric acid levels in diabetic and non-diabetic populations.
    Author: Kuo KT, Chang YF, Wu IH, Lu FH, Yang YC, Wu JS, Chang CJ.
    Journal: J Diabetes Complications; 2019 Aug; 33(8):511-515. PubMed ID: 31176544.
    Abstract:
    AIMS: Our study aimed to investigate the influence of different glycemic statuses and their fasting plasma glucose/2-hour post-load glucose on uric acid level. METHODS: A total of 14,787 subjects were recruited after excluding subjects with medication for hyperuricemia or diabetes. Fasting plasma glucose (FPG), 2-hour post-load glucose (2hPG), and uric acid (UA) were measured. Then, subjects were divided into normal glucose tolerance (NGT), impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and diabetes. RESULTS: After adjustment for clinical variables, in NGT group, there was no significant relationship found between UA level and FPG. However, there was a positive association between UA level and 2hPG (β = 0.003, 95% CI: 0.002~0.004). A similar trend was also observed between UA level and 2hPG in IFG group (β = 0.004, 95% CI: 0.000~0.009) and IGT group (β = 0.005, 95% CI: 0.002~0.008), but relationship between UA level and FPG remained insignificant. In diabetes group, UA level was negatively associated with both FPG (β = -0.008, 95% CI: -0.010 ~ -0.007) and 2hPG (β = -0.005, 95% CI: -0.006 ~-0.003). CONCLUSIONS: In non-diabetic individuals, UA level increased with 2hPG, but not with FPG, and UA level was inversely associated with both FPG and 2hPG in diabetic population.
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