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  • Title: Neurotensin-like immunoreactivity generated by pepsin from human plasma and gastric tissue.
    Author: Mogard MH, Kobayashi R, Lee TD, Chen CF, Hagiwara M, Leung F, Reeve JR, Shively JE, Walsh JH.
    Journal: Regul Pept; 1987 Aug 17; 18(3-4):221-32. PubMed ID: 3118424.
    Abstract:
    The present study demonstrates precursors of neurotensin-like immunoreactivity (NTLI) endogenous to human gastric tissue and plasma, and the existence of a gastric NTLI-generating enzyme system. The molecular size of the NTLI-precursors in plasma and gastric tissue were estimated by gel permeation chromatography to be ca 50,000-60,000 and 60,000-70,000 Da, respectively. The neurotensin-like peptide generated from the precursor was detected with a carboxyl-terminally directed antiserum but did not cross-react with an amino-terminally directed antiserum. A neurotensin-like peptide isolated from pepsin-treated human plasma was characterized by mass spectrometry and its amino acid sequence determined. This novel nonapeptide, referred to as kinetensin, failed to affect pentagastrin-stimulated acid secretion or blood pressure in the rat. Sequence homologies between neurotensin, kinetensin and proteins of the serum albumin family suggest a common evolutionary origin and raise questions regarding albumin-like proteins as precursors of regulatory peptides.
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