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  • Title: [The activity of enzymes of amino acid metabolism of the placenta in different terms of the physiological and complicated pregnancy.].
    Author: Pogorelova TN, Gunko VO, Mikhelson AA, Nikashina AA, Mikhelson AF, Lebedenko EY.
    Journal: Klin Lab Diagn; 2019; 64(5):260-264. PubMed ID: 31185147.
    Abstract:
    The activity of amino acid metabolism enzymes and the content of free amino acids in the placenta during physiological pregnancy and placental insufficiency (PI) were studied using spectrophotometric methods and ion-exchange chromatography. It was found that in PI placental activity of the studied enzymes: alanine-, cysteine-e, tyrosine-, glutamino- transferase, glutathione synthetase, glutamate dehydrogenase decreases at different periods of gestation. The opposite variations occur for aspartataminotranferase and glutaminase. Similar changes are detected for amino acids synthesized or used in the course of appropriate reactions: aspartic acid, glutamic acid, glutamine, alanine, cysteine, tyrosine, arginine. The correlation between enzyme activity and amino acid content was revealed. Different periods of pregnancy are characterized by varying degrees of change, especially expressed in the second trimester, characterized by the most intense growth and development of the fetus, and its increased needs for trophic material. The revealed changes obviously play a pathogenetic role in the formation and further development of PI.
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