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  • Title: Hepatosplenic γ-δ T-Cell Lymphoma: Who Is on Your Speed Dial?
    Author: Krishnan M, Lunning M.
    Journal: J Oncol Pract; 2019 Jun; 15(6):307-312. PubMed ID: 31185190.
    Abstract:
    Hepatosplenic γ-δ T-cell lymphoma, an exceptionally uncommon subtype of peripheral T-cell lymphomas, commonly presents with advanced-stage disease manifesting with hepatosplenomegaly, cytopenias, and constitutional symptoms. Management of this subset is challenging as a result of the unique presentation and refractory nature to conventional treatment approaches. There is a lack of consensus guidelines for up-front induction strategies, and the role of consolidative autologous or allogeneic stem-cell transplantation is controversial. Prospective studies are lacking, and treatment is often guided by literature on the basis of case series or single-institution studies, lending to expert opinions influencing treatment paradigms.
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