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  • Title: [Effect of diets of various levels of linoleic acid on prostanoid biosynthesis and arterial blood pressure in rats].
    Author: Zadkova GF, Markov KhM.
    Journal: Vopr Pitan; 1987; (4):56-60. PubMed ID: 3118572.
    Abstract:
    The authors studied the influence of diets with 0 cal % (diet 1), 9 cal % (diet 2, control) and 16 cal %, according to linoleic acid, on the arterial blood pressure (ABP) and exogenous biosynthesis of prostacyclin (PGI2), PGF2 and PGE2 from 14C-arachidonic acid in isolated aortal rings and thromboxane (TxA2), PGF2 alpha, PGE2 in the suspension of washed platelets. It was established that diet 1 used during 4.5 months led to a rise in the ABP and decreased biosynthesis of all the prostanoids studied, as compared to the control. Linoleic acid excess (diet 3) induced a more pronounced elevation of the ABP and reduction of PGI2 synthesis in the aorta and TxA2 in the washed platelets, as compared to the control.
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