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  • Title: Isolation of Neisseria meningitidis strains with increase of penicillin minimal inhibitory concentrations.
    Author: Sáez-Nieto JA, Fontanals D, Garcia de Jalon J, Martinez de Artola V, Peña P, Morera MA, Verdaguer R, Sanfeliu I, Belio-Blasco C, Perez-Saenz JL.
    Journal: Epidemiol Infect; 1987 Oct; 99(2):463-9. PubMed ID: 3119361.
    Abstract:
    We report the isolation and characterization of ten strains showing an increase in the minimal inhibitory concentrations to penicillin (MICs greater than 0.1 microgram/ml), and describe the epidemiological, clinical and microbiological features. The susceptibility of 3432 meningococcal strains isolated from patients in the recent epidemic wave (1978-86) in Spain, to several antimicrobial agents used in the treatment and chemoprophylaxis of meningococcal infection has been tested. Most were resistant to sulphadiazine but sensitive to other antibiotics. The possible existence of a new pattern of behaviour of meningococcal to penicillin is discussed.
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