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  • Title: Neurofibrillary tangles and the neuronal cytoskeleton.
    Author: Anderton BH, Brion JP, Flament-Durand J, Haugh MC, Kahn J, Miller CC, Probst A, Ulrich J.
    Journal: J Neural Transm Suppl; 1987; 24():191-6. PubMed ID: 3119774.
    Abstract:
    Antibodies to neurofilaments and the microtubule-associated protein, tau, have been used with anti-paired helical filament (PHF) serum to study Alzheimer neurofibrillary tangles. Tangles and their constituent PHF contain epitopes derived from or cross-reactive with both neurofilaments and tau proteins. These same structures are labelled with anti-PHF antibodies. A component of the anti-PHF serum is against tau proteins. We conclude that PHF are at least in part derived from an abnormal neuronal cytoskeleton.
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