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  • Title: Growth hormone responses to hp GRF 1-44 amide, bromocriptine and stress in acromegaly are correlated.
    Author: Belchetz PE.
    Journal: Postgrad Med J; 1987 Apr; 63(738):241-4. PubMed ID: 3120167.
    Abstract:
    The results of testing growth hormone (GH) reserve using human pancreatic growth hormone-releasing factor 1-44 amide (hp GRF 1-44 amide) have been compared with the GH responses in a variety of other dynamic tests in seven acromegalic patients. The GH release following hp GRF 1-44 amide correlated with the GH suppression following bromocriptine, but showed an inverse correlation with the GH release following stress tests (insulin-induced hypoglycaemia/glucagon). There was no correlation between the GH responses in these three tests and any of the other tests: TRH, GnRH and glucose. A hypothesis is proposed to explain these findings on the basis of varying degrees of GH secretion from adenomatous and normal pituitary somatotrophs in acromegaly.
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