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  • Title: A pyrazole-containing hydrazone for fluorescent imaging of Al3+ in lysosomes and its resultant Al3+ complex as a sensor for F.
    Author: Wang Y, Song YF, Zhang L, Dai GG, Kang RF, Wu WN, Xu ZH, Fan YC, Bian LY.
    Journal: Talanta; 2019 Oct 01; 203():178-185. PubMed ID: 31202324.
    Abstract:
    A fluorescence-enhanced and lysosome-targeted Al3+ probe (1) based on a pyrazole-containing hydrazone was developed in this work. The fluorescent probe 1 displays an OFF-ON fluorescence response to Al3+ in the lysosome pH environment. In addition, the resultant 1-Al3+ complex could act as an ON-OFF fluorescence sensor for F-. Fluorescence imaging shows that 1 is suitable for visualization of Al3+ in lysosomes of HeLa cells.
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