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  • Title: High-dose methotrexate and leucovorin rescue in dogs with osteogenic sarcoma.
    Author: Cotter SM, Parker LM.
    Journal: Am J Vet Res; 1978 Dec; 39(12):1943-5. PubMed ID: 312044.
    Abstract:
    Five dogs with ostoegenic sarcoma were treated by surgical removal of the primary tumor and by adjuvant chemotherapy. Methotrexate at dosages of 3 to 6 g/m2 was used with leucovorin rescue. All dogs tolerated E g of methotrexate/m2 of body surface, but granulocytopenia precluded escalation beyond this dosage in 4 dogs. The rate and time of appearance of pulmonary metastases were not altered by treatment, with all dogs developing metastases at a median time of 4 months after amputation.
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