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  • Title: Role of membrane-bound haemoglobin products in oxidative damage in sickle cell membranes.
    Author: Rice-Evans C, Baysal E.
    Journal: Acta Haematol; 1987; 78(2-3):105-8. PubMed ID: 3120454.
    Abstract:
    Even though the development of the membrane abnormalities in sickle cell erythrocytes is due to the presence of a mutant gene product, sickle cell anaemia is in a sense a membrane disease. In particular, the presence of iron-containing breakdown products of haemoglobin in the sickle cell membranes provides a source of continued oxidative damage. An understanding of the primary causes of these membrane abnormalities may be useful in the development of effective therapies.
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