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  • Title: In vitro study on α-amylase and α-glucosidase inhibitory activities of a new stigmastane-type steroid saponin from the leaves of Vernonia amygdalina.
    Author: Anh HLT, Vinh LB, Lien LT, Cuong PV, Arai M, Ha TP, Lin HN, Dat TTH, Cuong LCV, Kim YH.
    Journal: Nat Prod Res; 2021 Mar; 35(5):873-879. PubMed ID: 31204853.
    Abstract:
    Using various chromatographic separations, four compounds, including one new steroid saponin named vernoamyoside E (1), were isolated from the leaves of the Vietnamese medicinal plant Vernonia amygdalina Delile (Asteraceae). Their structures were established by spectroscopic methods such as 1D- and 2D-NMR, HR-ESI-MS, and HPLC analysis. The inhibitory activities against α-glucosidase and α-amylase of the isolated compounds from V. amygdalina were reported for the first time. The results indicated that compound 1 significantly inhibited both against α-amylase and α-glucosidase activity.
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