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  • Title: [HLA A-B and DR in dilated myocardiopathies].
    Author: Komajda M, Raffoux C, Salame E, Colombani J, Grosgogeat Y, Cabrol C, Dausset J.
    Journal: Arch Mal Coeur Vaiss; 1987 Jul; 80(8):1233-7. PubMed ID: 3120659.
    Abstract:
    HLA A, B typing was performed in 90 patients (90 men, 10 women), and HLA DR typing in 49 patients with dilated cardiomyopathy in order to test the hypothesis that a particular genetic background may influence the immune response in that disease. No significant difference in phenotype frequency of the HLA A and B antigens was observed between patients and control population. In contrast, the HLA DR4 antigen was significantly more frequent among patients (40.8% vs 23.8%, p corrected less than 0.001). The results suggest that genetic factors play a role in the pathogenesis of dilated cardiomyopathy, and that since DR4 is frequently associated with auto-immune manifestations, a modified immune response is possible in dilated cardiomyopathy.
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