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  • Title: Orbital optic glioma in neurofibromatosis. Magnetic resonance diagnosis of perineural arachnoidal gliomatosis.
    Author: Seiff SR, Brodsky MC, MacDonald G, Berg BO, Howes EL, Hoyt WF.
    Journal: Arch Ophthalmol; 1987 Dec; 105(12):1689-92. PubMed ID: 3120679.
    Abstract:
    In a patient with neurofibromatosis and orbital optic glioma, T2-weighted axial magnetic resonance images showed a fusiform area of high signal intensity with a central linear core of lower signal intensity. Computed tomographic images did not show a corresponding variation in tumor density. Histopathologic examination of the tumor revealed dense, circumferential, perineural glial proliferation. This "arachnoidal gliomatosis" is a feature of orbital optic gliomas in neurofibromatosis and, in our magnetic resonance scans, accurately corresponded with the region of high signal intensity within the tumor.
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