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  • Title: The study of T-, B-, O- lymphocytes in acute lymphoblastic leukemia.
    Author: Bogusławska-Jaworska J, Chybicka A.
    Journal: Arch Immunol Ther Exp (Warsz); 1978; 26(1-6):859-66. PubMed ID: 312091.
    Abstract:
    The T-, B-, and O-lymphocyte count changes were studied during the long-term intensive therapy of 43 ALL children. The control group consisted of 17 healthy children. The T-lymphocytes were identified by spontaneous formation of rosettes with sheep erythrocytes, the B-lymphocytes by EAC-rosette test. Patients were treated according to different program of multiple drug therapy and prophylactic cranial irradiation. During the study the applied therapeutic protocol produced the marked reduction of T- and B- lymphocytes. The decrease of B- lymphocytes was especially pronounced. The preliminary analysis suggests correlation between the reduction of T- and B- lymphocytes and prognosis.
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