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  • Title: The binding of thio-TEPA in human serum and to isolated serum protein fractions.
    Author: Hagen B, Nilsen OG.
    Journal: Cancer Chemother Pharmacol; 1987; 20(4):319-23. PubMed ID: 3121202.
    Abstract:
    Binding of triethylenethiophosphoramide (thio-TEPA) in serum from healthy individuals and from cancer patients and its binding to isolated serum protein fractions were studied by equilibrium dialysis. A drug-protein binding in the order of 10% was demonstrated in serum, with little interindividual variation. The protein binding of thio-TEPA seemed to be restricted to albumin and lipoproteins, with the greatest affinity to albumin. The previously reported selective binding of thio-TEPA to gamma globulin was contrary to our findings. The almost insignificant degree of serum protein binding of thio-TEPA indicates that the drug is well suited for use in cancer drug combinations.
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