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  • Title: Isolation of a Novel Reassortant Highly Pathogenic Avian Influenza (H5N2) Virus in Egypt.
    Author: Hagag NM, Erfan AM, El-Husseiny M, Shalaby AG, Saif MA, Tawakol MM, Nour AA, Selim AA, Arafa AS, Hassan MK, Hassan WMM, Fahmy HA, Ibraheem E, Attia M, Abdelhakim AMM, Shahein MA, Naguib MM.
    Journal: Viruses; 2019 Jun 18; 11(6):. PubMed ID: 31216712.
    Abstract:
    Highly pathogenic avian influenza (HPAI) H5N1 and H5N8 have become endemic among domestic poultry in Egypt since 2006 and 2016, respectively. In parallel, the low pathogenic avian influenza H9N2 virus has been endemic since 2010. Despite the continuous circulation of these subtypes for several years, no natural reassortant has been detected so far among the domestic poultry population in Egypt. In this study, the HPAI (H5N2) virus was isolated from a commercial duck farm, giving evidence of the emergence of the first natural reassortment event in domestic poultry in Egypt. The virus was derived as a result of genetic reassortment between avian influenza viruses of H5N8 and H9N2 subtypes circulating in Egypt. The exchange of the neuraminidase segment and high number of acquired mutations might be associated with an alteration in the biological propensities of this virus.
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