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  • Title: Human colorectal cancer derived-MSCs promote tumor cells escape from senescence via P53/P21 pathway.
    Author: Li G, Zhang R, Zhang X, Shao S, Hu F, Feng Y.
    Journal: Clin Transl Oncol; 2020 Apr; 22(4):503-511. PubMed ID: 31218648.
    Abstract:
    PURPOSE: The purpose of this study was to evaluate effect of MSCs on CRC cell. METHODS: in this study the MSC was isolated from CRC tissue, its effect on CRC cells was investigated in vivo and vitro, and the underlying mechanism was investigated. RESULTS: In this study we found that MSC-CM could promote colorectal cancer cells escape from senescence both in vitro and in vivo. Further research we demonstrated that MSC-CM acted in colorectal cancer cells senescence through P53/P21 pathway. Next we found that MSC-CM regulate P53 via posttranscription method. CONCLUSION: Collectively, these results reveal that MSCs can help colorectal cancer cells defend against senescence through P53/P21 pathway, which may be a new strategy for colorectal cancer therapy.
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