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  • Title: Association of interleukin-10-1082 (-1087) A > G polymorphisms and periodontitis risk: An updated meta-analysis based on 26 case-control studies.
    Author: Li Y, Hu B, Feng G, Chen Q, Zhu M, Ying S, Song J.
    Journal: Ann Hum Genet; 2019 Sep; 83(5):299-309. PubMed ID: 31222730.
    Abstract:
    BACKGROUND: The association between interleukin-10 (IL-10)-1082 (-1087) A > G polymorphism and either chronic (CP) or aggressive periodontitis (AgP) susceptibility was conflicting. This meta-analysis aimed to quantitatively estimate the association. METHODS: Pubmed, Embase, Web of Science, and WANFAN databases were searched for relevant studies that were submitted prior to January 31, 2018, and meta-analyses were performed using STATA 14.0. RESULTS: Database mining yielded 26 studies of interest. For the IL-10-1082 (-1087) A > G (rs1800896) polymorphism and its relation to CP susceptibility, the overall analysis showed no significant estimates, but subgroup analysis revealed significant associations in the AA versus GG + GA model in the Caucasian population (odds ratio [OR] = 1.274, 95% confidence interval [CI] = 1.069-1.518, P = 0.007; I2  = 0.0%, P = 0.483) and in the GG versus AA + AG model in the Han population (OR = 6.66, 95% CI = 7.72-9.41, P = 0.000; I2  = 0.0%, P = 0.82), which all showed no obvious publication bias by Egger's linear regression test. For the association between an IL-10-1082 (-1087) A > G polymorphism and AgP susceptibility, the overall analysis and Caucasian subgroup analysis yielded nonsignificant estimates. CONCLUSIONS: Our meta-analysis indicated that the IL-10-1082 (-1087) AA genotype in the Caucasian population, and the GG genotype in the Han population might be putative risk factors for CP. PRACTICAL IMPLICATIONS: The IL-10-1082 (-1087) AA genotype and the GG genotype might be potential biomarkers for Caucasian CP and for Han CP, respectively. However, additional research will be required to validate the findings of this meta-analysis.
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