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  • Title: Pertussis and cholera toxin ADP-ribosylation in Dictyostelium discoideum membranes.
    Author: Khachatrian L, Klein C, Howlett A.
    Journal: Biochem Biophys Res Commun; 1987 Dec 31; 149(3):975-81. PubMed ID: 3122750.
    Abstract:
    We report a 39 kDa substrate for cholera and pertussis toxins is present in D. discoideum membranes. This protein did not co-migrate with alpha subunits of either Gs (45 kDa and 52 kDa) or Gi (41 kDa) from control mammalian cells. The presence of GTP or its non-hydrolyzable analogs enhanced the ADP-ribosylation in response to cholera toxin, but did not significantly alter ADP-ribosylation by pertussis toxin. Divalent cations inhibited the ADP-ribosylation by both toxins. The possible association of this novel G-protein with D. discoideum adenylate cyclase may underlie some of the unique regulatory features of this enzyme. Alternatively, this G-protein may regulate one of several other cellular responses mediated by the cAMP receptor.
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