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  • Title: [Progress on numerical simulation of the deposition of inhaled particles in human pulmonary acinus region].
    Author: Li P, Li R, Qiao Y, Xu X.
    Journal: Sheng Wu Yi Xue Gong Cheng Xue Za Zhi; 2019 Jun 25; 36(3):499-503. PubMed ID: 31232555.
    Abstract:
    The inhalation and deposition of particles in human pulmonary acinus region can cause lung diseases. Numerical simulation of the deposition of inhaled particles in the pulmonary acinus region has offered an effective gateway to the prevention and clinical treatment of these diseases. Based on some important affecting factors such as pulmonary acinar models, model motion, breathing patterns, particulate characteristics, lung diseases and ages, the present research results of numerical simulation in human pulmonary acinus region were summarized and analyzed, and the future development directions were put forward in this paper, providing new insights into the further research and application of the numerical simulation in the pulmonary acinus region. 颗粒物的吸入和在人体肺腺泡区的沉积可能引发肺部疾病，采用数值模拟方法研究肺腺泡区吸入颗粒物的沉积状况，对肺部疾病的预防和临床治疗具有重要意义。本文从肺腺泡模型、模型运动方式、呼吸模式、颗粒物特性、肺部病变以及年龄等影响数值模拟结果的重要因素出发，分类总结了肺腺泡区数值模拟的研究进展，分析了现有研究的不足和局限，提出了未来发展重点研究的方向，以期为肺腺泡区数值模拟的进一步研究和应用提供参考和借鉴。.
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