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  • Title: Change in the relative importance of oestrone and oestradiol synthesis by the rat ovary between fetal and prepubertal stages.
    Author: Weniger JP, Zeis A.
    Journal: J Reprod Fertil; 1987 Nov; 81(2):479-83. PubMed ID: 3123657.
    Abstract:
    Ovaries of rat fetuses at 20 and 21 days and of neonatal rats at 5 and 14 days were cultured in the presence of [3H]testosterone, and the conversion percentages into oestrone (E1) and oestradiol (E2) were determined by double isotopic dilution combined with recrystallization to constant specific activity. Insignificant in the 20- or 21-day-old fetus, oestradiol synthesis increased relative to oestrone synthesis in the 5-day-old neonate (E1/E2 = 3.4) and still more at the stage of 14 days (E1/E2 = 0.78). FSH had no effect on oestrogen synthesis at the 4 stages investigated.
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