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  • Title: Testicular toxicity induced by single dosing of di- and mono-(2-ethylhexyl) phthalate in the rat.
    Author: Teirlynck O, Kaufman JM, Bogaert MG, Roels H.
    Journal: Toxicol Lett; 1988 Jan; 40(1):85-91. PubMed ID: 3124304.
    Abstract:
    The testicular toxicity of di-(2-ethylhexyl) phthalate (DEHP), a widely used plasticizer, and of its major metabolite, mono-(2-ethylhexyl) phthalate (MEHP), was assessed after a single dose in rats. Treatment with a single dose of 2.8 g/kg DEHP or 0.8 g/kg MEHP was sufficient to induce testicular atrophy as observed 7 days after dosing. Such a treatment had no effect on plasma FSH levels, and had varying effects on testicular zinc concentrations. After a single dose of 0.8 g/kg MEHP the testicular toxicity was age-dependent, in that only prepubertal rats were susceptible.
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