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  • Title: Absence of endo-beta-N-acetylglucosaminidase activity in the kidneys of sheep, cattle and pig.
    Author: Song ZW, Li SC, Li YT.
    Journal: Biochem J; 1987 Nov 15; 248(1):145-9. PubMed ID: 3124807.
    Abstract:
    The kidneys of man, sheep, cattle and pig were all found to contain 1-aspartamido-beta-acetylglucosamine amidohydrolase activity. However, among these, only human kidney was found to contain endo-beta-N-acetylglucosaminidase activity. The absence of this enzyme in the kidneys of sheep and cattle explains why the oligosaccharides accumulated in, and excreted by, sheep and cattle afflicted with disorders of glycoprotein catabolism (i.e. alpha-mannosidosis and beta-mannosidosis) contain two N-acetylglucosamine residues at the reducing terminus instead of one, as is the case for human patients afflicted with similar disorders.
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