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  • Title: Rapid evolution in the immunochemical findings of a gamma heavy chain disease.
    Author: Pontet F, Gué X, Dosquet C, Caen J, Rousselet F.
    Journal: Clin Chem; 1988 Feb; 34(2):439-43. PubMed ID: 3124986.
    Abstract:
    We noted the following major immunochemical changes in the final course of a gamma heavy-chain disease associated with a myelomonocytic leukemia: an important oligoclonal increase of IgG1/kappa, during sepsis development, whereas the lambda molecules decreased and IgG2 and IgG3 completely disappeared in a one-month interval. Initial concentrations of IgG4 were stable during that period, and gamma 1 heavy chains were slightly increased. This is a very unusual observation of the successive immunochemical events terminating a gamma heavy-chain disease.
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