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  • Title: Isolation and characterization of abl gene sequences in Calliphora erythrocephala.
    Author: Durica DS, Restrepo MA, Thomas TL, Beckingham K.
    Journal: Gene; 1987; 59(1):63-76. PubMed ID: 3125084.
    Abstract:
    Screening of genomic DNA libraries with hybridization probes derived from a Drosophila melanogaster c-abl proto-oncogene homologue resulted in the isolation of a set of related sequences from the dipteran Calliphora erythrocephala. Although the region encompassing the c-abl protein kinase domain encodes a polypeptide extremely similar to the Drosophila gene, considerable inter- and intraspecific divergence is found adjacent to this region. Restriction-site heterogeneity and cross-hybridization studies between individual cloned isolates suggest that abl homologues represent a small gene family in the Calliphora genome. As is the case in Drosophila, abl-related transcripts appear to be low in abundance, are synthesized during oogenesis and stored as a maternal mRNA.
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